Archive: Stochastik Rhein-Main

Events

Date Category Speakers Title

20.02.2019 Stochastik-Kolloquium Frankfurt

Metrische Multidimensionale Skalierung

Read more

31.10.2018 Stochastik-Kolloquium Frankfurt

Rekonstruktion zufällig verkürzter Zeichenketten

Read more

18.11.2019 Stochastik-Kolloquium Frankfurt

Prof. Dr. Dirk Metzler (FB Biologie/ LMU München)

Hybridzone zwischen Rabenkrähen und Nebelkrähen: Artbildung allein durch Paarungspräferenzen?

Read more

30.10.2019 Stochastik-Kolloquium Frankfurt

Prof. Dr. Hsien-Kuei Hwang (Academia Sinica, Taipeh)

Stirling numbers of the second kind: the history of early developments and an elementary approach to asymptotic normality

Read more

22.01.2020 Stochastik-Kolloquium Frankfurt

Crossing a fitness valley as a metastable transition in a stochastic population model

Read more

28.05.2021 Stochastik-Kolloquium Frankfurt

Dr. Jon Warren (Department of Statistics, University of Warwick)

A family of local times studied as a Markov process

Read more

06.06.2024 Stochastik-Kolloquium Frankfurt

B cell phylodynamics and mean-field multi-type birth and death processes

No knowledge of biology will be necessary to understand this talk. Germinal centers (GC) are micro-anatomical structures that transiently form in lymph nodes during an adaptive immune response. In a GC, B cells—the cells that make antibodies—diversify and compete based on the ability of the antibodies they express to recognize a foreign antigen molecule. As GC B cells proliferate, they undergo targeted mutations in the genomic locus encoding the antibody protein that can modify its antigen binding affinity. Via signaling from other GC cell types, the GC can monitor the binding phenotype of the B cell population it contains and provide survival signals to B cells with the highest-affinity antibodies (i.e., birth and death rates depend on type). Motivated by this mechanism, we develop a mean-field model that couples the birth and death rates in a focal multi-type birth and death process (MTBDP) with D types to the empirical distribution of states—i.e., the mean-field over an exchangeable system of N replica MTBDPs. The empirical distribution process of the N replicas converges to a deterministic probability measure-valued flow as N goes to infinity. In the limit, the focal process evolves as a multi-type birth and death process with rates governed by the probability measure-valued flow which is in turn the flow of one-dimensional marginal distributions of the focal process. Individual focal processes become independent in the limit and this holds out the hope of inference being feasible for this model. This is joint work with William S. DeWitt, Ella Hiesmayr, and Sebastian Hummel. Read more

Displaying results 201 to 207 out of 207